This corpus-based, semantic account of the multifunctional nature of discourse markers in conversational Colombian Spanish, significantly contributes to research on the semantics-discourse pragmatics relationship and on polysemy in discourse. It is shown that, in contrast with popular belief, discourse markers do not just constitute functional particles with indeterminate or context-based meanings, but that they also possess inherent meanings that can be identified and defined via the Natural Semantic Metalanguage methodology. This book presents a semantic analysis of a set of four functionally related discourse markers that are particularly frequent in conversational Colombian Spanish. A corpus of four hours of spontaneous conversation is used to study the markers bueno 'well, OK', pues 'well, then', o sea 'I mean, that is to say' and entonces 'so, then'. Through a detailed analysis of numerous examples drawn from the corpus, and employing both quantitative and qualitative techniques, it is demonstrated that, contrary to popular belief, discourse markers are not just functional particles with indeterminate or context-based semantics. Rather, they have inherent meanings which can be identified and exhaustively defined with an appropriate semantic methodology, such as is provided by the Natural Semantic Metalanguage approach. This study illustrates that this approach, which has been widely applied to the semantics of the lexicon and the grammar, can be extended to the semantics of discourse-based features, supporting the notion that meaning of all aspects of language forms one semantic system. This research also has implications for the study of polysemy, in that it operationalizes the little understood, but classical definition of polysemy of items with 'a shared element of meaning', and it demonstrates that the polysemous relations of discourse markers are centered around an invariant core that can be identified on the basis of their use in discourse.