This collection consists of thirteen contributions focusing on the latest trends of information structure and agreement, couched in the most current developments of Minimalism, Cartography, and Optimality. Some papers focus on the syntax of information structure in relation with the position occupied by different constituents in the CP domain and their interpretation such as the distinction between contrastive and corrective focus; the inclusion of given information in focus; the interplay of information structure and binding; the relative position of complementisers; and discourse-based constituents in the left periphery. Information structure is also analysed with regards to prominence phenomena at word level. Other papers deal with the notion of agreement and its role in the syntax of specific constructions such as applicatives, correlatives, or different types of CP like relatives or embedded interrogatives. This selection of papers was originally presented at the 21st Colloquium on Generative Grammar, held at the University of Seville in April 2011.