A number of conversation analytic studies have suggested that asymmetries of knowledge and access to knowledge and experience contribute to the organization of the interaction. Building on previous research on the epistemics of social relationships, this paper draws on audiotaped doctor-patient data and uses the methodology of conversation analysis to examine one practice for managing access to knowledge and dealing with issues related to epistemic status in Polish talk-in-interaction – no-prefacing. This analysis shows that turn-initial no in responsive turns takes from the local (sequential) context and the participants’ respective epistemic frames involved and becomes the participants’ resource for managing their socioepistemic relationships toward a collaborative, corroborative or competitive outcome.