This paper explores efficient effective communication in the midst of multi-varied cultures at Ibis West Africa, assuming a qualitative approach of the constructivist’s paradigm. Misinterpretations, misperceptions and misunderstandings of both verbal and non-verbal cues as well as differences in generating common meaning of messages encoded and decoded and the mindlessness of the communication setting marked the interactions between the expatriate workers and the local staff of Ibis West Africa. The paper advised that Ibis West Africa could center more on intercultural relationship and capacity building amid their multicultural staff to increase efficient communication in this multinational organisation.