This inquiry explores facework strategies of managing face-threatening acts in intercultural interactions where communicators’ cultural backgrounds are different from each other. Based on a pre-study with U.S. (n = 89) and Chinese (n = 76) college students, four scenarios featuring intercultural face-threatening acts were evolved, where a Chinese student communicated politely and suitably according to the Chinese culture, but the exact same act was regarded otherwise in U.S. culture. In the chief inquiry, U.S. college students (N = 217) were given these scenarios and asked to report the general level of face needs, perceived face threats, and facework strategies in each scenario. Multilevel analyses (i.e., Hierarchical Linear Modeling) were used to parse out the different levels of impact in order to grasp both separate and joint impacts of situational face threats and individual face needs on facework strategies. Results displayed that: 1) intercultural communicators employ both mitigating (i.e., fleeing) and aggravating (i.e., fighting) facework strategies, and a slight preference is given to mitigating strategies; 2) facework strategies are more sensitive to specific situational conditions than to individual dispositions; and 3) individuals’ value for others’ face mitigates the relationship between situational conditions and facework strategies. This inquiry supplies empirical evidence of challenges in constructing meaningful intercultural relationships by distinguishing the multiple levels of impact on facework strategies in intercultural communication.