Depending on how it is employed, humor can have both positive (Lang and Lee 2010. Workplace humor and organizational creativity. The International Journal of Human Resource Management 21(1). 46–60) and negative (Moran and Hughes 2006. Coping with stress: Social work students and humour. Social Work Education 25(5). 501–517) effects on well-being in the workplace. Even when attempts at humor are well meant, they may end up being misread and doing more harm than good. This article proposes that humor can be employed in the workplace to cultivate better relationships, generate a more positive work environment, and avert unintended harmful effects of misplaced or misused humor. Findings are proposed that explore the relationship between humor and well-being, with social support serving as the mediator. The positive relationship between humor and well-being is clarified via enhanced social support in the workplace. These findings propose that conflicting results in the relationship between humor and well-being could be explained via the theory that only certain types of humor (like positive humor) enhance social support, and therefore well-being. These findings can be employed to help employees and managers grasp how to better employ humor to have positive effects in the workplace.