This inquiry revises research concerning the effects of source physical attractiveness on persuasion with focus on the interplay with source gender and receiver gender. Most evidence points out that attractive female sources tend to be more persuasive than unattractive ones in attitudinal and behavioral measures. The results for male sources are ambiguous, with few studies reporting the liability of male source attractiveness. Recipients’ sex is a poor predictor of source attractiveness influence for both male and female sources. The inquiry’s contribution synthesizes decades of research on source attractiveness to propose future research ideas for academics in marketing, psychology, and communications and to give recommendations for marketers, advertisers, and other practitioners aiming to impact people’s attitudes.