Based on a self-administered online survey of undergraduate students, this inquiry examines college students’ social media involvement in relation to their stress coping in the United States and China. A total of 262 and 265 survey responses were received from respectively American and Chinese participants. Results pointed out that American student users’ positive strategic social networking sites (SNS) involvement to a certain extent assisted in their adaptive coping with stress. However, the positive effect of positive strategic SNS involvement was not found as an adaptive coping strategy among Chinese student respondents. In addition, perceived support from friends on Facebook was the key mediator of positive strategic SNS involvement and adaptive coping for U.S. students.