This inquiry proposes semantic ambiguity norms for 530 Spanish words. Two subjective measures of semantic ambiguity and two subjective measures of relatedness of ambiguous word meanings were gathered. In addition, two objective measures of semantic ambiguity were covered. Farther, subjective ratings were attained for some pertinent lexicosemantic variables, like concreteness, familiarity, emotional valence, arousal, and age of acquisition. In sum, the database surmounts some of the restrictions of the published databases of Spanish ambiguous words; especially, the paucity of measures of ambiguity, the lack of relatedness of ambiguous word meanings measures, and the absence of a set of unambiguous words. Thus, it will be very useful for researchers interested in examining semantic ambiguity as well as for those employing semantic ambiguous words to study language processing in clinical populations.