This study addresses the issue of politeness in compliment responses (CRs) among Iranian female university students. Using naturally occurring talk, 235 compliment-response exchanges were recorded during focus group interviews. The findings revealed that to mitigate impoliteness the interviewees displayed five extreme culture-specific politeness strategies as (1) tarof, (2) shekasteh-nafsi, (3) hyperreciprocation, (4) sha’n, and (5) double positive response. In female-female CR exchanges, interviewees attempted to foster a good impression by resorting to politeness strategies of tarof, hyperreciprocation, and double positive response whereas in male-female CR exchanges, interviewees tried to undermine the appraised impression imposed by the opposite-sex compliments through politeness strategies that are anchored in sha’n and shekasteh-nafsi. This article concludes that Iranian women respond diversely to compliments by virtue of interaction among integrated components: the compliment topic, the complimenter’s sex, and cultural burdens.