Reading is a challenging task for Chinese as a second language (CSL) learners. Research has shown that effective use of strategies helps to enhance reading comprehension. However, studies about the reading strategies of CSL learners are extremely limited, and even fewer studies focus on how CSL readers use reading strategies to facilitate comprehension when reading a Chinese text. This case study addressed this gap by conducting an in-depth analysis of how three CSL readers used strategies to enhance their comprehension. Through think-aloud and recall protocols, close observations, and interviews, this study identified 26 comprehension strategies used by these readers during the reading process. It also reported the strategies commonly used by these readers to enhance reading comprehension effectively, such as using context to decode words, monitoring, identifying important information, and skipping unimportant parts. This article presents the study’s findings and their implications.