Within psychological effects of multiculturalism, it is often underscored that multiculturalism and interculturalism reduce ethnocentrism. This empirically poorly bolstered supposition was tested on high-school students from South Bačka District in the Autonomous Province of Vojvodina, in northern Serbia, a multicultural setting. This study treats languages as the most significant culture carriers, and it is adopted that the extent of multilingualism could be linked with the level of generalised ethnocentrism. Subjects (N = 354, mean age 18.3 years) were divided into a group with lower, and a group with higher degree of multilingualism based on the self-assessment of their language skills in the languages learned in school or acquired and used in their environment, and they filled in the Generalized Ethnocentrism Scale. The group with higher degree of multilingualism showed lower level of ethnocentrism. The difference between the groups is of medium intensity. Higher openness is more prominent in female participants and students that have better average school grades.