This study is an attempt to address the issue of examining the relationship between burnout and personality among translation students. Recent trends in student/academic burnout have led to a proliferation of studies which have heightened the need for the exploration of this construct that is well-grounded in personality influences. Despite increasing concern over these two concepts, no report has been found so far surveying their association within the translation discipline. To this end, 73 Iranian translation students completed a 33-item student translator burnout scale and the 44-item Big Five Inventory of Personality. This was also accomplished by building a causal structural model through which the associations among these constructs were estimated. The results demonstrated that the proposed model has a good overall fit with the empirical data. Findings further provide evidence that there are significant correlations between agreeableness, neuroticism, and burnout. Keywords: modélisation par équations structurelles, translation practice, personality, translation student burnout, translator's performance, personnalité, épuisement académique des étudiants en traduction, structural equation modelling, performances du traducteur, pratique de la traduction