The Direct and Mediational Inference model of comprehension (DIME) assumes that general inference processes mediate the effects of reader resources on general comprehension proficiency. The current study proposes an extension of DIME, the Inferential Mediation Model (IMM), to account for comprehension as it occurs while reading a particular text. The results of this study support the DIME and IMM, and suggest that inference processes that support mental model construction mediate the impact of reader resources on comprehension.