Region of residence, wealth status, education, marital status and religious affiliation were found to significantly predict knowledge and awareness of HIV/AIDS among Ghanaian women. In addition, pregnancy status and place of residence proved to be significant correlates of HIV/AIDS awareness among Ghanaian women. The inquiry suggests that higher social status is critical in determining whether women of reproductive age are aware of and knowledgeable about the epidemic. Health messages ought to be deliverable via mobile phones.