This paper handles irony expression in Italian Sign Language (LIS), i.e. signing something while meaning its contrary. Four Deaf native Italian Sign Language signers were given a Discourse Completion Task to get a semi-spontaneous induction of 10 minimal pairs of ironic/literal remarks putting either praises or criticisms. The assay of this corpus disclosed that: sentence meaning is manually conveyed via the polarity of the evaluative lexical sign; signer's conduct is conveyed non-manually via mouth-corners up and down; ironic remarks display a lengthy articulation; and irony might be farther notified by non-obligatory non-manual and manual cues.