This chapter sets out to explore the impact of language, and more particularly, of translation, on the reaction of Italian end-users of humorous stimuli contained within translated audiovisual products. The research design created to measure these responses is described and results pertaining to a number of studies in which the same protocol was applied are reported. As the appreciation of humor is not solely cognitive - in other words, it cannot be limited to comprehension alone - the chapter will also examine the concept of "sense of humor" and whether, and if so to what extent, it is lingua-cultural specific and/or how it is dependent on individual personality traits.