This paper deals with the adaptation of graphic novels to animated film. It analyses the award-winning Arrugas (2007) about Alzheimer’s disease, written and drawn by Spanish author Paco Roca, and adapted to the 2D animated film Arrugas. Wrinkles. Engurras (2011). Firstly, in order to put the novel into context, the authors give an overview of different genres dealing with Alzheimer’s. They then present some details about the author, the plot and the peculiarities of publication. Their analysis focuses on the differences between the comic and the film version a) in depicting the doctor-patient interaction and b) in linguistic variation in dialogue.