Translation between Chinese and English seems to be more difficult than that between any two European languages, because the fact that the two languages are of two different language families, namely, Indo-European and Sino-Tibetan, gives rise to many more differences in mode of expression, grammar, syntax, meaning system. Therefore, the translation teacher faces greater challenges in training translators who are in greater demand in our era of globalization. The article first presents the major difficulties in the translation between Chinese and English, and then offers some solutions.