Following its rediscovery and publication in the early part of the 16th century, Heliodorus' Aithiopika quickly came to enjoy a high reputation throughout Europe. This long and complex prose romance, which probably dates from the third or fourth century CE, was extensively imitated by Sydney in the Arcadia and by Tasso in Gerusalemme Libertata. In this article, the author discusses Shakespeare's Cymbeline and the author identifies how Heliodorus' highly sophisticated romance has been a guide in telling this well-known tale of a calumniated wife.